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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disorder characterized by maternal pruritus in the latter half of the pregnancy, raised serum bile acids and increased rates of adverse fetal outcomes. Maternal effects of ICP are mild; however, there is a clear association between ICP and higher frequency of fetal distress, preterm delivery, and sudden intrauterin fetal death. The etiology of ICP is elusive but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. The mechanisms by which fetal complications occur is also unclear. In this article we tried to review epidemiology, clinical features, etiology, diagnosis, pharmacologic treatment and obstetric management of ICP. Abbreviations: Intrahepatic cholestasis of pregnancy (ICP), Familial intrahepatic cholestasis (PFIC), Benign Recurrent Cholestasis (BRIC), Cholic Acid (CA), Chenodeoxycholic Acid (CDCA), Ursodeoxycholic Acid (UDCA), Neonatal Respiratory Distress Syndrome (RDS), Meconium-Stained Amniotic Fluid (MSAF), Royal College of Obstetricians and Gynaecologists (RCOG), Progressive Familial İntrahepatic Cholestasis (PFIC), Contraceptive-İnduced Cholestasis (CIC), Adenosine Triphosphate-Binding Cassette, Subfamily B, Member 4 (ABCB4), Multidrug Resistance 3 (MDR3), Respiratory Distress Syndrome (RDS).

Management of Intrahepatıc Cholestasıs of Pregnancy: Revıew of Lıterature