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In an inter-laboratory experiment, different laboratories determine some characteristic, e.g. the concentration of an analyte in one or various homogeneous samples under documented conditions. Several subtypes of inter-laboratory studies can be distinguished. Collaborative trials or method performance studies are used to test the performance (generally the precision) of a single analytical method. A standard method, which is routinely used in several laboratories, can also be examined collaboratively to test for a possible bias of either the method (method bias) or the laboratories (laboratory bias) that routinely use it [1]. Quality control is a measure of precision, or how well the measurement system reproduces the same result over time and under varying operating conditions. Laboratory quality control material is usually run at the beginning of each shift, after an instrument is serviced, when reagent lots are changed, after calibration, and whenever patient results seem inappropriate [2] Interpretation of quality control data involves both graphical and statistical methods. Quality control data is most easily visualized using a Levey-Jennings charts. The dates of analyses are plotted along the X-axis and control values are plotted on the Y-axis. The mean and one, two, and Abstract: Laboratory quality control is designed to detect, reduce, and correct deficiencies in a laboratory's internal analytical process prior to the release of patient results, in order to improve the quality of the results reported by the laboratory. The study was done to assess the quality control monitoring and evaluation of Bilirubin & alkaline phosphates and also for inter-laboratory studies of some electrolytes in Nisa Premier Hospital Abuja and the Benue State University Teaching Hospital Makurdi, North central Nigeria. The quality control monitoring & evaluation of Bilirubin and Alkaline phosphates were conducted for two consecutive months using the spectrophotometer (kenza240 TXbiolabo France), and the inter laboratory studies was done and the following electrolytes (K, Na, Cl, TCO2 ) were determined in blood samples at both locations. At both locations determination was performed using Ion Selective Analyzer AC9900 (Audicom, China).The results of quality control showed that Trends (loss of reliability) and shifts (abrupt changes in the control mean) were noted in the results of this study, there were two major trends in July and more shifts in the month of August than in the month of July for bilirubin and two violations of the Westgard Rule for Alkaline phosphates. The results of inter-laboratory assessment of Electrolytes shows a great difference in the mean values of K + between the laboratories in NiSA (3.29 ± 0.40) and BSUTH (12.23 ±4.65) but imprecision was within acceptable performance. This is similar for all other analytes (Na + , TCO2-) with exception of Clwhich clearly indicated marginal performance. The results of the study shows that both imprecision and bias exist between both laboratories but imprecision was within Acceptable performance.

international journal of clinical chemistry and laboratory medicine

Quality Control Monitoring &amp; Evaluation of Bilirubin, Alkaline Phosphates and Inter-Laboratory Assessment of two Hospitals in North Central Nigeria