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Newer insights into the pathogenesis of coronary artery disease reveals that maintaining normolipedemia therapeutically or by life style modifications does not attenuate the risk of CAD. Research reveals that in addition to concentration, qualitative parameters of lipoproteins needs attention . Small dense LDL is more atherogenic and large HDL is no more functionally competent. HDL particle size captures key place as a novel diagnostic marker. This case –control study done on 50 CAD patients and 50 age and sex matched healthy individuals revealed that CAD patients had a higher mean HDL particle size and lower concentrations of Apo-A1 and paraoxonase-1 activity, though the concentrations of HDL were significantly higher in cases due to statin therapy. Hence to assess risk in individuals consideration of HDL particle size along with lipid profile would be essential. It’s cheap and cost effective by measuring apo-A1 concentrations and deriving particle size by HDL/Apo-A1 ratio.

HDL Particle Size and Its Association with Paraoxonase - 1 Activity in CAD Patients