English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Squamous cell carcinoma (SqCC) of vaginal vault post total abdominal hysterectomy may arise from either any remnant of cervix or from vagina, but the exact origin is difficult to decipher. SqCC of vaginal vault with metastases to liver, adrenal and brain without local recurrence is very uncommon and rarely heard of. We hereby report a 57 year-old-female who had underwent total abdominal hysterectomy 15 years ago developed SqCC of the vaginal vault and was treated with concurrent chemo -radiotherapy. Response assessment imaging with positron emission tomography scan 3 months post therapy showed complete resolution of the vault primary but appearance of metastatic lesion in liver and adrenal which were proven from image guided fine needle cytology. She was started on palliative chemotherapy and functional imaging after 5 cycles of chemotherapy showed complete resolution of the metastatic lesions. However, within one month she presented with severe headache and vomiting. Magnetic resonance imaging of brain revealed multiple intracranial metastatic lesions for which she received palliative whole brain radiotherapy to which she responded significantly and has been kept on follow-up and supportive care. This case is being presented to highlight the interesting and unusual case scenario we encountered, the clinical course of the disease, the management aspects and overall prognosis.

Squamous Cell Carcinoma of Vaginal Vault with Liver, Adrenal and Brain Metastases: Report of an Uncommon Presentation