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In order to study antitumor and antimetastatic activity of polysaccharide from Helianthus tuberosus L. in vitro and in vivo models were chosen. Hep-2 (laryngeal) and L-929 (mice fibroblasts) were taken for in vitro studies. Also to investigate antimetastatic activity of natural glucan the high-affinity strain of Walker carcinosarcoma was used, which forms tumor nodules after intravenous injection. Dose-dependent activity of polysaccharide was also studied. Stimulation of Nk-cells activity by HTLP was shown. Conclusion about immunological way of antimetastatic and antitumor activity was made. To verify antimetastatic activity and influence on primary tumor by polysaccharide was Lewis lung-carcinoma model was also taken.

Antimetastatic and Tumor Growth Inhibition Activity of Polysaccharide from Helianthus Tuberosus L.