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Patients with hyperthyroidism usually responding well to the conventional antithyroid medications. 1 If these drugs are failed or there is side effect, then surgery or radioiodine therapy must be considered. 2 When thyroidectomy or radioactive iodine therapy are the treatment options, then the patient should be treated first with antithyroid drugs like methimazole (MMI) or its pro-drug, carbimazoleor propylthiouracil (PTU) until his (T4) become normal or near normal to prevent complications like; thyrotoxic crisis or exacerbation of ophthalmopathy. Betablockers, corticosteroids, or inorganic iodide may also be used as adjunctive treatment for more prompt control. 3 Few patients with hyperthyroidism are resistant to antithyroid drugs and adjunctive therapy. Certain literatures reported that the cholestyramine, when used with antithyroid medication, produce a more rapid decline in serum thyroid hormone levels. 4-

Resistant Hyperthyroidism, Responses Dramatically to Adjunctive Oral Cholestyramine