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Fluorescence spectroscopy (FS) has been studied for the early detection and classification of tissues alterations of the oral mucosa. In the present non-randomized prospective trial we investigate tissue changes using FS, at 532 nm excitation, in oral cancer in situ and immediate ex vivo resected specimen with particular attention to the surgical margins. A total of 22 patients with OSCC and 20 volunteers with normal mucosa were submitted to analysis system of FS in the exam of the subjects mucosal with oral cancer (lesions and surgical margins) and health volunteers (in several oral sites). In lesions and surgical margins the examination was carried out in situ and ex vivo. All analyzes were correlated with the pathological diagnosis. In all patients with OSCC, we observed differences in the spectra of the border of the lesions versus surgical margins versus normal mucosa, these degree of similarity was calculated by anatomic site. The degree of similarity ranged from 15 to 50 percent depending on the anatomical site and healthy or altered mucosa, and followed the same pattern between different individuals. Differences were also observed in the moments in situ and ex vivo from the same patient. There is in all patients with OSCC distinct behaviors regarding the form and intensity considering different oral sites showed in FS, and we saw the usefulness of FS to discriminate tissue changes in surgical margins.

Analysis of the Surgical Margins of the Oral Cancer using in Situ and Ex Vivo Fluorescence Spectroscopy