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Lung cancer is the most common cancer worldwide [1] . It causes more deaths per year than other cancers and the mortality has been high for recent decades among both men and women [2] . Non-small cell lung cancer (NSCLC) epitomizes the most frequently diagnosed subtype of this fatal malignancy [3] . Over the past 50 years, NSCLC accounts for 85% to 90% of lung cancer, especially squamous cell carcinoma (SCC) and adenocarcinoma (ADC) [4] . There are many causes for lung cancer. Smoking, including passive exposure to tobacco, is the principal cause of lung cancer. However, many lung cancer patients did not have the history of smoking and a lot of smokers didn’t Abstract: Background: Long non-coding RNAs (LncRNAs) have been shown playing important roles in the pathogenesis and progression of multiple tumors. Meanwhile, we also identified some loci associated with emphysema distribution at genome-wide significance. It included a new association near TRAPPC9. So far, the effect of LINC01495 and TRAPPC9 polymorphisms on lung cancer risk were unclear. Rs2665675 and rs2665936 are single nucleotide polymorphisms located in LINC01495 and TRAPPC9, respectively. This study aimed to investigate the association between rs2665675 of LINC01495 and rs2665936 of TRAPPC9 polymorphisms and the risk of lung cancer in Northeast Chinese population.

A Case-Control Study of the Relationship between LINC01495, TRAPPC9 Polymorphisms and Lung Cancer Susceptibility in Northeast Chinese Population