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Rabies is a worldwide zoonotic disease caused by the lyssavirus and it causes an acute fatal encephalitis that affects all mammals. Therefore, this present study was conducted to assess the community knowledge, attitude and practice on rabies in Mersa town, Amhara region, Ethiopia. A cross-sectional study was conducted from January 2019 to March 2019 in Mersa town. A total of 138 respondents were randomly selected and interviewed using a semi-structured questionnaire to assess the public awareness and practices about the disease. Descriptive and inferential statistics were performed to describe the data. Based on the current assessment, the majority (83.33%) of the respondents haven't heard about rabies. The majority of the respondents (52.5%) replied that rabies can be prevented by vaccination but there were misperceptions on transmission and clinical signs of the disease. Out of 120 respondents, 42(35%) of them use herbal extract and traditional medicine as treatment of rabies. Furthermore, most (60.83%) of respondents let their dogs free in the environment. Also, only 20.83% of the respondents vaccinate their dogs regularly. Overall, respondents having higher education levels take immediate action when a person has bitten by a rabid animal and these are found statistically significant (p<0.008). Besides, mostly they kill a rabid animal and visit health centers soon after the bite and this was also significantly associated (p<0.048) with the level of the education of the respondents. Accordingly, the study showed that there was a low level of awareness and perception regarding rabies in the study community. Therefore, creating awareness to the community through training and public education should be implemented.

Assessment of Community Knowledge, Attitude and Practice towards Rabies in Mersa Town, Amhara Regional State, Ethiopia