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Alpha tocopherol as an antioxidant over the years has been used both for improved fertility and for other nutritive factors, cisplatin treatment results in anemia and hepatotoxicity, the ameliorative effects of Alpha tocopherol was studied to see the combined synergistic relationship of the administration of both cisplatin and alpha tocopherol which would help to reduce the negative effect of cisplatin treatment. 16 adult male rats where introduced into this study and broken into 4 study groups which includes the control group, I,II,III,IV. Alpha tocopherol was administered orally 0.5ml and cisplatin was administered intra-peritoneal 800mg kg -1 per body weight. The hematologic parameters where analyzed and compared, their weight gradients was also observed to investigate the effect of alpha tocopherol and cisplatin on the weight gradient. The results showed a remarkable improvement of the ameliorative properties of alpha tocopherol when compared with cisplatin, there was increased HCV and HGB hemoglobin concentration, the TWBC, total white blood cell count also increased in the treatment group with the combination of cisplatin and alpha tocopherol, there was increased body weight when compared with the cisplatin groups. This study further shows that alpha tocopherol has an anti-oxidative stress mechanism on the negative effect of cisplatin after chronic exposure.

international journal of research studies in microbiology and biotechnology

Evaluation of the Ameliorative Properties of Alpha Tocopherol on Cisplatin Treated Adult Male Wistar Rats “Its Heamatologic Parameters and Repair Mechanism”