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Progesterone has been seen as the main steroidal hormone mediating capacitation and acrosome reaction, the two basic processes which a sperm must undergo, in order to be successful in carrying out fertilization of ovum. Thus presence of progesterone receptors (PR) on the surface of spermatozoa and their role in fertilization is under intense investigation. This study analyzed around 25 semen samples using PCR (polymerase chain reaction) technique, shows that the mRNA (messenger ribonucleic acid) transcript for progesterone receptor is rarely present in fertile males. This has been confirmed by our repeated inability to detect the transcripts in case of fertile male samples. Although in some cases of infertility, bands corresponding to progesterone receptor transcripts were detected. This detection may be because of increased level of mRNA expression due to the abnormal pathological condition. However, we have also detected mRNA transcript of different sizes, which further raises a possibility of alternative splicing of progesterone receptor. These splice variants again raises a possibility of involvement of this phenomenon as a cause of infertility. Although further analysis need to be done.

Detection of Wild Type and Variant mRNA Transcript of Progesterone Receptor in Human Spermatozoa of Infertile Males