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The possibility of enhancement of absorption efficiency of Levofloxacin Hemihydrate, a synthetic quinolone antibiotic, was explored by the use of water-in-oil microemulsion system. This system was selected because of its higher reported membrane permeability according to both in vitro and in vivo studies. A microemulsion comprising tween 20/1-propanol/water and clove oil was developed and characterized by conductivity measurements, viscosity measurements and refractive index measurements. It was found that loading of the drug had no negative effect on the stability of the system. Measurement of the partition coefficient suggests that Levofloxacin hemihydrate is present in water droplets as well as in the continuous oil phase and may also be present at the interface.

Microemulsion-based Drug Delivery System for Enhancement of Absorption Efficiency of Levofloxacin Hemihydrate