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Hepatitis B virus infection is one of the major health problems in the world today with over one-third of the world's population (over two billion people) acutely infected with Hepatitis-B Virus; more than 240 million people are chronically infected by the virus. About 780,000 people die yearly as a result of the infection. Worse still, about 24-40 percent of the chronically infected carriers die from liver cirrhosis or Hepatocellular Carcinoma (HCC) a leading cause of cancer-related death worldwide and the burden of this devastating cancer is expected to increase further in coming years [13, 15]. Infact, hepatocellular cancer (HCC) alone accounted for over 500,000 deaths per year, making it the third leading cause of cancer mortality worldwide [1, 10, 11].

Optimal Control Strategy for Hepatitis B Virus Epidemic in Areas of High Endemicity