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Purpose: To observe the effects of Nv Shi solid drink on thyroid hormone, sex hormones and cyclic nucleotide of kidney-yin deficiency hyperthyroid mice induced by levothyroxine sodium. Methods: ICR mice were randomly grouped into normal control group, model group, Nv Shi solid drink high dose group, the middle dose group and low dose group, male and female in half. The kidney-yin deficiency mice models were established by intragastric administration of levothyroxine sodium before intragastric administration of corresponding drugs once a day for 10 consecutive days. One day after the last administration, the effects were observed by measuring weight. And tetraiodothyronine (T4), triiodothyronine (T3), thyrotropin (TSH), testosterone (T), estradiol (E2), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) were tested by ELISA method. Results: Compared with the model group, the body weight increased significantly (p<0.05), T3 level decreased significantly in high and medium dose group (p<0.01, p<0.05), and serum T4 and cAMP decreased significantly (p<0.01, p<0.05), TSH increased significantly (p<0.01, p<0.05) in all dose groups, and cAMP / cGMP decreased in the low dose group(p<0.05). The expression of E2 in female decreased significantly in all does groups, the same as the ratio of E2/T in high dose group(p<0.05). There was no significant change in the expression of sex hormones in male in all dose groups (p>0.05). Conclusion: Nv Shi solid drink may improve the kidney-yin deficiency syndrome by adjusting T3, T4, TSH, cAMP and E2 level in the endocrine system of the body and exert the function of nourishing yin and tonifying kidney.

Effect of Nv Shi Solid Drink on Endocrine Regulation in Mice with Kidney-Yin Deficiency Induced by Levothyroxine Sodium