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Purpose: Research with the aim of studying the effect of ileum interposition in hyperglycemia and pancreatic beta cell mass in nonobese diabetic rats. Methods: We used 18 Wistar rats randomly divided into 3 groups of 6 each. A non-diabetic control group, a diabetic control group, and diabetic with ileal interposition group. Induction of diabetes was underwent with streptozotocin. The beta cell mass was quantified by an indirect method by dividing the serum C-peptide (ng/mL) for blood glucose (mg / dL). We used variance (ANOVA) and Tukey's test for analysis of specific differences, considering the significance p <0.05. Results: The blood glucose of diabetic animals with ileal interposition was significantly lower (94.5 ± 5.6mg/dL) than in diabetic control rats (245 ± 4.8 mg / dL) (p <0.05). The C-peptide levels showed significantly higher in diabetes interposition group (0.58 ± 0.06 ng / mL) than in control diabetes group (0.42 ± 0.03 ng / mL), suggesting a greater response to pancreatic stimulation in that group (p <0.05). The ratio of C-peptide and glucose levels showed a higher beta cells mass in diabetic interposition animals (0.61) than in control diabetes (0.004), and the difference was significant (p<0.05). Conclusion: The results showed that the ileal interposition contributed to the reduction of blood glucose and to increase the mass of functioning beta cells in diabetic rats.

journal of surgical and clinical research

Ileal interposition for the treatment of diabetes in rats: repercussion on beta cells mass Tratamento do diabetes pela interposição ileal em ratos: Repercussão na massa de células beta