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The Heck reaction plays an important role in organic synthesis because of the versatility of aryl halides and olefins that can be employed. Therefore, a synthetic route to chlorambucil through the Heck reaction was proposed. However, the oxidative addition of the proposed halide to the palladium catalyst was not sucessful. An alternative Heck-Matsuda approach showed better results for the synthesis of a carboxylic acid derivative of chlorambucil.

The Heck reaction applied to the synthesis of chlorambucil