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Lidocaine (LDC) is a local anesthetic that can be used for post-surgical or cancer related pain, via intravenous infusion or bolus. An alternative to maintain drug plasma levels are the sustained release carriers, whereas nanostructured lipid carriers (NLCs) stand out; they have biocompatibility, low toxicity, reproducibility and high efficiency in the transport of hydrophobic drugs.This work aims to study the solubility parameter of the LDC pre formulation in several ultra-purified lipids, compatible with the endovenous route, and to formulate NLCs based on these lipids for LDC encapsulation.

Nanostructured lipid carriers with ultra purified lipids for sustained release of intravenous lidocaine