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Morphological-functional characteristics of nasal polyps were studied in 88 patients with rhinosinusitis polyps. The tissue of a polyp had typical picture, multi-rows ciliated epithelium with a large number of goblet celts. Different stages of polyp maturation were observed: from edematous to perivascular and diffuse cellular infiltrates consisting of eosinophils, lymphocytes and mast cells. Their presence proves allergic nature of rhinosinusitis, which as any pathology process by stress is accompanied. At the early stage, chronic stress downregulate pro-inflammatory cytokines, while upregulating the anti-inflammatory cytokines. All the steps induced continued increased pro-inflammatory cytokines and finally inflammation, which induce various diseases. The final stage of polyp maturation was characterized by fibrous induration of its stroma with cirrhosis signs.

MORPHOLOGY OF NASAL POLYPS IN PATIENTS WITH ALTERED IMMUNOLOGICAL REACTIVITY