English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The authors show maximum neuroprotective efficacy of hypoxia and hypercapnia combined effect in comparison with their isolated use. They discuss the role of possible mechanism of this A-1 receptors efficacy to adenosine, mitochondrial ATP-sensitive potassium channels, apoptosis, cellular synthetic activity, chaperones, neurotrophic protein S-100b, stress of the endoplasmic reticulum, HIF-1a transcription factor. The hypothesis about carbon dioxide potentiation of neuroprotective efficacy of hypoxia is formulated. The prospects of clinical use of hypercapnic hypoxia in neurology are considered.

NEUROPROTECTIVE EFFECT MECHANISMS OF HYPOXIA AND HYPERCAPNIA COMBINED IMPACT