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A new synthetic extractive protocol for the synthesis of Cu(II) and Co(III) complexes of bis(2,2 / -methylylidenephenol)diaminoethane (H2BMPDE) in a single simple step was performed. The obtained data indicated the formation of complexes with 1:1 molar ratio of metal:ligand, of distorted square planar and distorted octahedral geometries. In vitro antibacterial screening revealed that the complexes were active against clinically important gram-negative bacteria (Escherichia coli, pseudomonas, and gram-positive bacterium (Staphylococcus aureus). The synthesis of the complexes was optimized to make it more suitable and efficient for industrial scale production.

Synthesis, Optimization, Characterization and Antimicrobial Studies of Cu(II) and Co(III) Complexes of Bis(2,2/-methylylidenephenol)diaminoethane