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Aim: To estimate and compare serum β2-microglobulin levels in oral leukoplakia and oral squamous cell carcinoma patients with that of control group. Material and Methods: The study was carried out on 70 subjects divided into three groups (20 oral leukoplakia patients, 30 oral squamous cell carcinoma patients and 20 controls). Serum β2-microglobulin was estimated by an enzyme linked immunosorbent assay (ELISA). Results: A significant increase in serum levels of β2-microglobulin was observed in oral squamous cell carcinoma patients as compared to control group. Conclusions: Results of this study suggest that estimation of serum β2-microglobulin can be useful in as biomarker for diagnosis of oral squamous cell carcinoma.

Estimation and comparision of serum β2-microglobulin in oral squamous cell carcinoma and oral leukoplakia