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Microfluidics is a multidisciplinary technological field that explores the manipulation of small amounts of fluids in miniaturized systems, allowing the manipulation of single or multiphase flows and promoting new routes to the production of polymer particles. Chitosan is a cationic biopolymer applied in pharmaceutical and medical fields, including drug and gene delivery. When glycosylated, it presents a broader biological applicability due to its solubility in water at all pH conditions. This research explores the synthesis of chitosan and glycol chitosan nanoparticles with polyelectrolyte sodium tripolyphosphate (TPP), using a microfluidic process configuration with a central aqueous stream. The produced nanoparticles were characterized in terms of zeta potential, hydrodynamic diameter and polydispersity index.

Microfluidic platforms for the synthesis of Chitosan and Glycol Chitosan nanoparticles