Metabolomic study of patients with bipolar disorder through ¹H Nuclear Magnetic Resonance (¹H NMR).

The Bipolar Disorder (BD) is a psychiatric illness that affects 1% of the global population. Having in mind that diagnostics of the BD is difficult and based only on clinical evaluation, our current research has as objective the comparison of the metabolic profiles between Healthy Control (HC) group and the BD patients. Also, we aim to find the substantial differences that can suggest biomarkers for BD and, finally, to connect them with pathophysiological conditions of this disorder. To enlarge results obtained in previous studies of BD biomarkers (done with limited number of BD patients), the blood serum samples were analyzed using 1H Nuclear Resonance Magnetic (NMR) spectroscopy and chemometric methods in the data analysis. As result, the most important regions in the 1H NMR spectra responsible for samples classification into two groups have been identified to be from 1.0 to 4.0 ppm and confirmed our previous results. Until now we have analysed 22 serum samples from the BD patients and 26 samples of HC Group. The expectation is to analise 100 samples, 50 of each group. Our partial results point 18 metabolites as possible biomarkers for the BD, among which myo-inositol, coline, valine, lactate, creatine, threonine, L-aspartate and GABA are the most important.