English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The insulin resistance is especially caused by inflammatory process in obesity. The activation of antiinflammatory cholinergic pathway is responsible to attenuatte inflammation. The objective was investigate if the obese offspring have cholinergic antiinflammatory signalling damage and insulin resistance impaired. The inflammation LPS-induced was able to increase pIKK, IL-6, pSTAT3 levels and decrease gluconeogenesis in lean and obese offspring. The treatment seems to reduce α7nAChR in offspring and increase to pAKT in obese offspring. Our datas indicate which the maternal obesity impaired the cholinergic signalling and this can be affect glucose homeostasis through IL-6 signalling.

Obese offspring mice have impaired inflammatory response after chronic treatment with LPS