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Isotretinoin is a synthetic compound similar to vitamin A, widely used in dermatological treatments for severe acne. This compound can be considered a potentially harmful factor for the male reproductive tract causing structural changes because it is directly related to cell proliferation and differentiation. Considering the lack of information about this effect our study was directed to evaluate the epididymis structure with light microscopy associated to findings about isotretinoin use and potentially affected organs.

Structural observation of the epididymis after dose dependent Isotretinoin treatment of juvenile Wistar rats