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Diabetes mellitus is a multisystemic disease characterized by hyperglycemia due to defects in insulin secretion and action, or both. Hyperglycemia is the most important factor in the onset and progress of diabetic complications. Hyperglycemia increases the expression of receptor for advanced glycosylation end products (RAGE) which leads to pancreatic -cells damage. Yellow soybean (Glycine max) is reported to contain isoflavones which have various biological properties including antidiabetes. Dietary soybean can prevent the progression of diabetic complications. This study was conducted to investigate the effects of yellow soybean powder suspension on expression of RAGE and pancreatic -cells damage of diabetic rats. Thirty streptozotocin (STZ)- induced diabetic Sprague Dawley male rats aged 11-12 weeks with body weight 200-250 g were used in this study. The rats were divided into 5 groups with 6 rats in each group. Group 1 was non diabetic rats. Group 2 was diabetic rats without treatment. Group 3-5 were given yellow soybean powder suspension of 400, 800 and 1600 mg/kg BW for four weeks, respectively. At the end of the experiment, pancreases tissues were removed for examination of RAGE expression and pancreatic -cells. The results showed that yellow soybean powder suspension ingestion signifantly decreased blood glucose level of diabetic rats toward normality (p 0.05). Meanwhile, the percentage of RAGE expression on Group 4 (42.43±4.08%) and Group 5 (40.62±3.42%) were significantly lower than Group 2 (p 0.05), whereas the percentage of pancreatic -cells in Group 4 (16.78±7.79%) and in Group 5 (22.03±11.51%) were significantly higher than Group 2 (p<0.05). In conclusion, yellow soybean powder suspension can decrease RAGE expression and prevent pancreatic -cells damage on STZ-induced diabetic rats. Keywords: pancreatic cells - Langerhans islets - streptozotocine - diabetic rats - soybeans

berkala ilmu kedokteran/journal of the medical sciences

Expression of receptor advanced glycation end products (RAGE) and histological picture of pancreatic -cells of streptozotocin-induced diabetic rats after yellow soybean powder suspension (Glycine max) administration