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Postanesthetic shivering (POS) is a common complication following spinal anesthesia. Several drugs have been used to prevent POS, including ondansetron and pethidine. This study was conducted to compare the efficacy of ondansetron 8 mg with pethidine 0.4 mg/kg BW for prevention of shivering in pregnant patients undergoing a cesarean section with spinal anesthesia. This is a double blind controlled trial involving 96 pregnant patients between the age 18-40 years with ASA physical status I-II, gestational age of 37-42 weeks, body weight of 40-70kg or Body Mass Index (BMI) 145 cm who underwent a cesarean section with spinal anesthesia in Dr. Sardjito General Hospital, Yogyakarta and affiliated hospital. Exclusion criteria included patients or families who refused to participate in the study, having a history of allergy to bupivacaine, ondansetron, and pethidin, patients with a fetus known to have congenital abnormalities earlier, body temperature early > 38 oC or 0.05). The incidence of nausea on the ondansetron group (4.2%) was lower than the pethidine group (16.7%) (p 0.05). In conclusion, the efficacy of ondansetron 8 mg is comparable to pethidine 0.4 mg/kgBW for prevention of shivering in pregnant patients after spinal anesthesia.

berkala ilmu kedokteran/journal of the medical sciences

The efficacy of ondansetron in comparison with pethidine for prevention of shivering in pregnant patients undergoing a cesarean sectionwith spinal anesthesia