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Conjugated linoleic acid (CLA) is an isomer of linoleic acid that has been shown to have many beneficial effects in prevention of atherosclerosis, hypertension, cardiovascular diseases and improve immune function. Although majority of CLA in the diet are derived from dairy product such as milk, however, the content of CLA in milk is affected by cow’s diet. The aim of this study was to investigate the beneficial effect of CLA supplementation in milk for improving lipid profile in high fat diet of rats. Twenty four male Sprague Dawley rats aged 8 weeks were given high fat diet for 3 weeks to induce hypercholesterolemia. Six rats were maintained in standard diet as control. Rats then were divided into 4 groups i.e. normal control, negative control, high fat diet+CLA 0.5%, high fat diet + CLA 0.5% supplemented skim milk, and high fat diet + CLA 0.5% supplemented whole milk. Blood sample was drawn after high fat diet induced hypercholesterolemia and after 4 weeks of treatment for total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL cholesterol), and high density lipoprotein cholesterol (HDL cholesterol) analysis. Body weight was measured each week. Results showed that body weight was significantly increase in all groups received high fat diet (p 0.05). Total cholesterol, triglyceride, and LDL cholesterol was significantly decrease in whole milk followed by significant increase in HDL cholesterol level. Skim milk supplemented with CLA had only modest effect on triglyceride and HDL cholesterol level. In conclusion, CLA supplementation in whole milk improves lipid profile in high fat diet.

Addition of conjugated linoleic acid in whole milk improves lipid profile in high fat diet induced hypercholesterolemia of rats