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The decrease of proliferation level of cells in several regions of adult brain is found after stress exposure. One of such area is prefrontal cortex. Herbal medicine as antistress has been used widely. Centella asiatica (L) Urban extract was reported to have potent compounds to increase brain function. The objective of this study is to investigate the effects of ethanolic extract C. asiatica on cell proliferation of the adult prefrontal cortex in rats (PFC) after chronic stress. Adult male Sprague-Dawley rats, weighing 260-390 g were randomly assigned into six experimental groups, with five rats per group, i.e. Group 1 as nomal control without chronic stress, Group 2 as stress control, Group 3 as positive control given fluoxetine, Group 4-6 as treatment groups given 150; 300 and 600 of ethanolic extrac C. asiatica, respectively. Extract were administered orally to the rats following a period of restraint duration of 6 hours/day for 21 days. Bromodeoxyuridine (BrdU) immunohistochemistry was used to label the proliferated cells. Physical fractionator method was used to estimate the total number of proliferated cells. One-way analysis of variance (ANOVA) followed by Tukey post hoc test was used to evaluate the difference between groups. BrdU-labeled cells on medial prefrontal cortex were as follows: 1715.3±1345.1 (Group 1), 2659.2±2250.6 (Group 2), 4077.4±2415.3 (Group 3), 1784.1±908.3 (Group 4), 3056.6±4263.3 (Group 5), and 2153.4±2259.4 (Group 6). No significance difference between groups was observed (p>0.05). In conclusion, the administration of ethanolic extract of C. asiatica does not influence cell proliferation on prefrontal cortex of rats after chronic stress.

Prefrontal cortex cell proliferation of adult rats after chronic stress treated with ethanolic extract of Centella asiatica (L) Urban.