English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

We evaluated the response of cardiac resynchronization therapy (CRT) in ischemic cardiomyopathy (ICMP) and non-ischemic cardiomyopathy (NICMP). We determined if the cause of cardiomyopathy, ischemic versus non-ischemic, affects CRT outcomes in regard to New York Heart Association (NYHA) category and ejection fraction. We used a retrospective chart review for adult patients who underwent biventricular device placement between January 2005 and July 2015 at the university of Toledo medication center as part of their standard of care. NYHA category and ejection fraction were compared before and after CRT in both ICMP and NICMP patients. The NYHA category improved by 0.39±0.90 and 0.81±0.79 (p1⁄4 0.001) in ICMP and NICMP, respectively. The NYHA category worsened on follow-up in 11 (11.2%) patients in the ICMP group and five (5.2%) patients in the NICMP group (p1⁄4 0.12). A total of 50 (51%) patients in the ICMP group and 26 (26.8%) in the NICMP had no improvement in their NYHA category (po0.001). Thirty-seven (37.8%) patients in the ICMP group and 66 (68%) in the NICMP group showed improvement by one or more in their NYHA categories (po0.001). NICMP remained a significant predictor of response to CRT independent of other variables after controlling it using logistic regression analysis. The ejection fraction increased by 5.58±11.41 in ICMP compared with 12.86±14.55 in NICMP (p1⁄4 0.001). Our study shows an improvement in NYHA functional class and ejection fraction after CRT therapy in heart failure patients regardless of etiology. However, a more favorable outcome was noticed in the NICMP subgroup. A future randomized control trial with a control group that specifically addresses this question and investigates possible etiologies is warranted.

Clinical Efficacy of Cardiac Resynchronization Therapy in Patients with Ischemic and Non-ischemic Cardiomyopathy