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Humans have always been interested in animals. In the Paleolithic, several animals were drawn on the walls of caves with details showing the acute sense of observation of draughtsman. Among the ancient great civilizations, the Egyptians had already solid notions of anatomy and biology. In Mesopotamia, more than 2000 years ago, lists of living forms were engraved on tablets. From a long time man felt the need to recognize living forms, especially animals, and to classify them with certainly utilitarian and religious concern, some animals representing divinities endowed with magical powers.During Antiquity Aristotle (384322 BC) knew about 400 animal species which he classified inenaimaor red-blooded animals, and anaima, devoid of blood, corresponding approximately to vertebrates and invertebrates [1].

From the Knowledge of Biology to the use of Animal Model