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Core-shell Chitosan magnetic hydrogels containing encapsulated progesterone were prepared, and their biomedical application as a long acting and magnetic targeted system was evaluated. Magnetic hydrogels were cross-linked at different feed ratios of ionic liquid, and their gel forming ability, magnetic localization and drug release properties were examined. The hydrogels were loaded with progesterone at drug loading percentages ranging from 30 ± 2.75 to 37.50 ± 2.85%. The results obtained showed that ionic liquid-Fe3O4 core / chitosan shell magnetic hydrogel exhibited excellent drug encapsulation efficiencies and a sustained drug release profile with a highly controlled initial burst effect. The current study highlights the effect of pH on the loading and release characteristics of the magnetic hydrogel as a result of the change in the network architecture of chitosan. The concentration of ionic cross-linker showed a significant effect on the release profile of progesterone. The approach developed in this work can be potentially used to develop sustained release formulations of progesterone by controlling the chemical configuration of chitosan network.

"Multifunctional Ionic Liquid-Fe3O4 Core/Chitosan Shell Magnetic Hydrogel for Magnetic Responsive, pH-triggered and Long-Acting Hormone Therapy"