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The present study was performed to evaluate the effect of 28 days subchronic oral administration of AgNPs in normal and irradiated rats (4 Gy). Oxidative stress biomarker (blood glutathione, serum nitric oxide and liver MDA as an index for lipid peroxidation), also some inflammatory parameters as c-reactive protein and tumor necrosis factor alpha (TNF-α) have been measured. Liver DNA fragmentation was examined to determine the damaging effect in liver tissues by gel electrophoresis technique. Results of the present study revealed that blood glutathione significantly increased in irradiated treated group irradiated with (4Gy) then treated with (42.599 mg/kg) (1/10 LD50 in irradiated animals) and in irradiated group (4Gy) as compared to normal control but the increase is more in the irradiated treated group. NO has been significantly increased in irradiated and irradiated treated group but with a lesser extent in irradiated treated group. All groups showed significant decrease in CRP as compared to normal control group. liverDNA fragmentation showed a damaging effect exhibited by AgNPs (26.878 mg/kg) (1/10 LD50 in normal animals) and irradiated treated group but to a lesser extent than AgNPs group, whereas vehicle Polyvinylpyrrolidone (PVP) and irradiation groups showed a damaging effects. Based on the present study we can conclude that AgNPs has a modulating effect in decreasing the elevated level of NO caused by irradiation. Meanwhile AgNPs potentiate the effect of irradiation on increasing blood glutathione level, decreases the damaging effect on liver DNA fragmentation caused by irradiation. These results can be promising in cancer patients receiving radiation therapy and treated with AgNPs, or those receiving AgNPs for any other medical purpose but such results awaits further investigations.

british journal of pharmacology and toxicology

Subchronic Effect of Silver Nanoparticles Following 28 Days of Repeated Oral Administration on Oxidative Stress, Inflammatory Biomarkers and DNA Fragmentation in Normal and Irradiated Rats