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To clarify the frequencies of administration of the drugs possibly related to the haematopoietic disorders, three surveys were conducted in the periods of April-September 1972, October 1975 -March 1976, and October 1977-March 1978 by reviewing the health insurance receipts for the civil servants in Nagoya, Japan. Major findings are as follows. (1) Those who visited medical institutions at least once in the survey period of 6 months accounted for 71.9%, 62.2% and 70.1% among the total civil servants in the first, second and third survey, respectively. Among them, the relevant drugs were prescribed in 69.2%, 68.7% and 50.6%, correspondingly. (2) The prescription rates of chloramphenicols were 13.3%, 7.9% and 0.08% in the first, second and third survey. The corresponding figures were 1.2%,9.3% and 2.2% for thiamphenicols, 15.3%, 9.2% and 12.3% for sulfonamides, 40.0%, 51.5% and 40.9% for antipyretics, analgesics and seda­ tives. (3) The frequencies of a drug prescribed with other drugs in combination changed over years. Chloramphenicols were prescribed less frequently with sulfonamides and more frequently with penicillins, cephalosporins and thiamphenicols. The prescription of thiamphenicols with cepha­ 10sporins increased over years. (4) The prescription rates were different by age in individual drugs. The prescription rates were in general lower in the age group of 20-29 years than in the older age groups throughout three surveys.

Trend in prescription rates of drugs suspected to induce haematopoietic disorders in a population in Nagoya.