English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Helicobacter pylori (H. pylori) is a transmissible bacterium of the gastric mucosal surface that induce progressive damage in gastric epithelial cells (1). Since the historic report of the culture of spiral organisms and its characterization by the Barry Marshall and Robin Warren in 1984, it is known that more than 50% of world’s population is infected with this microaerophilic organism (2, 3). In 1994, the International Agency for Research on Cancer (IARC) declared H. pylori to be a group I human carcinogen for gastric adenocarcinoma (4). The second subsequent event in same year was that the national Institutes of Health (NIH) recognized that most recurrent duodenal and gastric ulcers were caused by H. pylori and thus chemotherapy was highly recommended (4). Thereafter, microbiologists and gastroenterologists decided to intensively focus on eradicating H. pylori infection (5). In this paper, I provide novel conclusive and straight data related to the management of H. pylori infection according to the policy for eradicating the infection (6). Moreover, an actual picture drawn by new paradigm against the H. pylori is clearly discussed with emphasis on therapy (7). 1Standard triple therapy (standard dose proton pump inhibitor, amoxicillin 1 g, and clarithromycin 500 mg twice daily for 7 to 14 days) is the highly recommended first-line regimen for eradication of H. pylori in many regions worldwide (8). Preferably, gastroenterologist admit that antibiotic therapy should be based on anti-microbial susceptibility tests but, they mostly have no other choices than empirical treatment. Clarithromycin-resistant H. pylori has become a problem in many regions and there is considerable interest in finding new treatment regimens that can be used without culture and sensitivity testing in diagnostic practice. Conclusively, designation of new insight for a therapeutic regimen is a priority for clinicians in close future. 2Not only a minority (1-5%) of population colonized with H. pylori develop gastroduodenal diseases, but also now we should consider even asymptomatic gastritis patients as subjects of antibiotic therapy as recent global consensus recommended (9, 10). It means a major shift in current therapeutic policies are necessary and we may have to think more about vaccine and other preventive choices (11). 3H. pylori infection should be considered as a major public health and hygiene concern, therefore, scientists can justify immediate elimination of the H. pylori in clinical practice. In other words, we should not discuss the risks and benefits of the treatment of H. pylori in symptomatic or asymptomatic subjects, since the only left question would be how to treat rather than whom to treat (10). Finally, in order to get rid of problematic reports of H. pylori colonization, clinicians’ optimal goal should be complete bacterial elimination from clinical and environmental samples. For future, novel antibacterials are needed to treat the increasing problem of resistance to H. pylori.

Time to Stop Helicobacter pylori, no Matter with Antibiotic, Probiotic or Vaccine