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Summary New assays for antibodies against artificially generated cyclic citrullinated peptides are of importance in the assessment of patients with suspected rheumatoid arthritis, especially during the early stages of the disease. These assays have similar sensitivity but are more specific for rheumatoid arthritis than the traditional rheumatoid factor test. The combined use of these assays and tests for rheumatoid factor provides more information than either test alone, particularly with respect to differentiating potential cases of rheumatoid arthritis from early cases of undifferentiated arthritis.

Abnormal Laboratory Results: Antibodies to cyclic citrullinated peptides: how they assist in the diagnosis of rheumatoid arthritis