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The use of herbal medicine is increasingly becoming more accepted in treatment of many inflammatory conditions. Omega-3 is recently introduced as an effective therapeutic agent and a powerful anti-inflammatory agent, which promotes whole-body wound healing including ulcers as it has an important role in modulation of proinflammatory cytokine production. This study was conductedto evaluate and compare the effect of topicalapplication and systemic administration of omega-3 on the healing of oral mucosal wounds which wereexperimentally induced in albino rats. The experiment comprised 45 albino rats which were divided into 3 groups (n= 15 per group); control group not receiving any treatment(C) group (L) receiving topical application of omega3, and group(S) receiving systemic omega3; 5 rats from each group were sacrificed at day 2, 4 and 8 respectively. Tissue samples were obtained and prepared for histological and biochemical evaluations. The data obtained were analyzed using one way ANOVA and Post Hoc Tukey statistical analysis with the previously performed tests of normality and homogeneity. The biochemical results showed significant improvement regarding TNFα and IL8-levels after 4 and 8 days in both groups compared to the control. The topical omega3 group showed better results than the systemic with significant differences at 4& 8 days inTNFα while for IL8 the difference was only significantafter 8 days. The histological results revealed severe epithelial degeneration and inflammation in the lamina propria after 2 days whether using local or systemic treatment however increase reepithelialization gradually increased at 4 days and an even thickness of the epitheliumwas noted by the end of day 8.

Assessment of the Topical and Systemic Effects of Omega-3 on Oral mucosal wound healing in albino rats: A Histopathological and Biochemical study