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Genetic factors play a substantial role in breast cancer etiology. Genes encoding proteins that have key functions in the DNA damage response, such as p53 and its inhibitors MDM2 and MDMX, are most likely candidates to harbor allelic variants that influence breast cancer susceptibility. The aim of our study was to comprehensively analyze the impact of SNPs in the TP53 , MDM2 , and MDMX genes in conjunction with TP53 mutational status regarding the onset and progression of breast cancer.

oncotarget

Specific allelic variants of SNPs in the <i>MDM2</i> and <i>MDMX</i> genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients