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Based on expression data, Epidermal Growth Factor Receptor (EGFR) emerged as therapeutic target in Head and Neck Cancer but clinical efficacy of EGFR inhibitors was very limited. We reinvestigated the EGFR expression and activation status necessary for response in cell lines and compared that to clinical samples.

oncotarget

EGFR overexpression is not common in patients with head and neck cancer. Cell lines are not representative for the clinical situation in this indication