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Development of receptive endometrium (RE) from pre-receptive endometrium (PE) is essential for embryo implantation, but the molecular mechanisms are not fully understood. In this study, lncRNA/circRNA-miRNA-mRNA networks were constructed to explore the functions of potential competing endogenous RNAs (ceRNA) during the development of RE in dairy goats. We observed that circRNA8073 (ciR8073) decreased levels of miR-181a by acting as a miRNA sponge. This effect indirectly increased expression of neurotensin in endometrial epithelial cells (EECs). Neurotensin in turn inhibited EEC apoptosis by increasing expression of BCL-2/BAX via the MAPK pathway, and also increased expression leukemia-inhibitory factor, cyclo-oxygenase 2, vascular endothelial growth factor A and homeobox A10. We have thus identified a ciR8073-miR181a-neurotensin pathway in the endometrium of dairy goats. Via this pathway, ciR8073 functions as a ceRNA that sequesters miR-181a, thereby protecting neurotensin transcripts from miR-181a-mediated suppression in EECs.

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation