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// Pingsheng Cai 2, * , Xuejing Jin 2, 4, * , Hua Zhu 3 , Shupin Zhu 2 , Lijie Wang 2 and Jing Jin 1 1 Institute of Glycobiological Engineering, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, Zhejiang, China 2 Department of Obstetrics and Gynecology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, China 3 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 4 Present address: Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China * These authors share co-first authorship Correspondence to: Jing Jin, email: jinjing@wmu.edu.cn Keywords: glycine decarboxylase (GLDC); O-GlcNAcylation; OGT; cervical cancer; metastasis Received: November 27, 2017 Accepted: January 03, 2018 Published: January 09, 2018 ABSTRACT Glycine decarboxylase (GLDC) is one of the glycine metabolic enzymes and was reported as a oncogene involved in tumorigenesis of non-small cell lung cancer. However, the function of GLDC in cervical cancer remains unclear. In this study, we determined the increased expression of GLDC in cervical cancer tissues and cell lines. The clinical pathological characters of GLDC revealed that increased GLDC expression was involved in cervical cancer metastasis. Further in vitro experiments confirmed the promotion of GLDC on cervical cancer metastasis. Furthermore, we found that OGT interacted with GLDC and modified GLDC with O-GlcNAcylation in cervical cancer cell lines. In addition, the O-GlcNAcylation of GLDC greatly enhanced its promotion on migration and invasion in vitro and in vivo . The clinical data further demonstrated the promotion of GLDC and OGT on cervical cancer metastasis, and showed that OGT worsened the prognosis of GLDC High patients. Collectively, this study identified OGT-mediated O-GlcNAcylation on GLDC as an essential regulatory mechanism for promoting cervical cancer metastasis, and provided a therapeutic target for metastatic cervical cancer.

OGT-mediated O-GlcNAcylation on GLDC promotes metastasis in cervical cancer