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// Qingwei Meng 1 , Shishuai Sun 1 , Shiqi He 1 , Baoming Shi 1 , Anshan Shan 1 and Baojing Cheng 1 1 Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P.R. China Correspondence to: Anshan Shan, email: asshan@neau.edu.cn Keywords: resveratrol; inflammation; microbiota; piglets; diarrhea Received: October 27, 2017 Accepted: January 02, 2018 Published: January 02, 2018 ABSTRACT Early weaning commonly results in gastrointestinal disorders, inflammation and diarrhea in infants and young animals. Resveratrol, a plant phenol, affords protection against inflammation and cancer. A porcine model was used to investigate the effects of maternal resveratrol supplementation on diarrhea, intestinal inflammation and intestinal morphology in offspring during weaning. Fecal microbiota and intestinal gene expression were measured by 16S rDNA sequencing and RNA sequencing (RNA-seq) analysis, respectively. Maternal resveratrol supplementation alleviated weaning-associated intestinal inflammation and diarrhea, and improved intestinal morphology in the offspring. In weaning piglets, maternal resveratrol supplementation increased the proportions of butyrate-producing bacteria, such as Flavonifractor , Odoribacter and Oscillibacter , as determined by 16S rDNA sequencing. RNA-seq analysis identified 189 and 139 differentially expressed genes (DEGs) in weaning and post-weaning piglets, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that DEGs were enriched for the T cell receptor, primary immunodeficiency, mitogen-activated protein kinase (MAPK) and Ras signaling pathways in weaning piglets and for the cytokine-cytokine receptor interaction pathway and metabolism-related pathways in post-weaning piglets.

oncotarget

WITHDRAWN: Maternal dietary resveratrol alleviates weaning-associated intestinal inflammation and diarrhea in porcine offspring by altering intestinal gene expression and microbiota