English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In this study, we aimed to determine the potential association of MTHFR tagging single nucleotide polymorphisms (SNPs) with risk of developing esophagogastric junction adenocarcinoma (EGJA). MTHFR rs1801133 G&gt;A, rs3753584 T&gt;C, rs4845882 G&gt;A, rs4846048 A&gt;G and rs9651118 T&gt;C polymorphisms were genotyped in 1,677 healthy individuals and 1,063 patients with EGJA. We found that MTHFR rs1801133 G&gt;A polymorphism was significantly associated with the risk of developing EGJA (AA vs. GG: adjusted P = 0.001; GA/AA vs. GG: adjusted P = 0.007 and AA vs. GA/GG: adjusted P = 0.001). However, for MTHFR rs4845882 G&gt;A polymorphism, the decreased risk of EGJA was found in two genetic models (AA vs. GG: adjusted P = 0.002 and AA vs. GA/GG: adjusted P = 0.005). In addition, for MTHFR rs3753584 T&gt;C and rs9651118 T&gt;C polymorphisms, a tendency to decreased risk of EGJA was noted. In a subgroup analysis, a significantly decreased risk of EGJA in &lt;64 years subgroup was identified. We found that MTHFR G rs1801133 T rs3753584 G rs4845882 A rs4846048 C rs9651118 , G rs1801133 C rs3753584 A rs4845882 A rs4846048 T rs9651118 and G rs1801133 T rs3753584 A rs4845882 G rs4846048 T rs9651118 haplotypes significantly decreased the risk of EGJA ( P = 0.002, P &lt; 0.001 and P = 0.038, respectively). In conclusion, our study demonstrates that MTHFR rs1801133 G&gt;A may be associated with the increased risk of EGJA. Meanwhile, MTHFR rs3753584 T&gt;C, rs4845882 G&gt;A and rs9651118 T&gt;C polymorphisms and haplotypes may decrease the risk of EGJA in Eastern Chinese Han population. Further studies with large sample size and detailed gene-environmental data are needed to validate our conclusion.

oncotarget

Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 Chinese Han subjects