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Background: This meta-analysis was performed to derive a more comprehensive estimation over the role of the single nucleotide polymorphism (SNP) rs2241766 in ADIPOQ gene in the occurrence of DN. Results: The overall ORs reflected a positive correlation between ADIPOQ rs2241766 polymorphism and susceptibility to DN under GG vs. TT and GG vs. TT + TG comparisons (OR = 1.51, 95% CI = 1.16–1.95; OR = 1.43, 95% CI = 1.11–1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in Caucasian and African subgroups as well as in type 2 diabetes mellitus (T2DM) subgroup. Materials and Methods: Relevant studies were searched from digital databases such as Embase, PubMed, Wanfang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixedor random-effects models. Inter-study heterogeneity was examined using Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of overall estimates. Begg’s funnel plot and Egger’s test were applied to inspect potential publication bias among included studies. Conclusions: ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DN, especially in Caucasian and African populations as well as in T2DM patients.

WITHDRAWN: Association between ADIPOQ rs2241766 polymorphism and risk of diabetic nephropathy