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Common variants of multiple genes played a crucial role in osteonecrosis of the femoral head (ONFH) onset which was proved by many previous reports. We hypothesized that polymorphisms in NOS3, ABCB1 and IL23R were related to individual differences in alcohol sensitivity and the development of alcohol-induced ONFH.

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Combination analysis ofNOS3,ABCB1andIL23Rpolymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males