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Glioblastoma is the most malignant tumor of the central nervous system and still lacks effective treatment. This study explores mutational biomarkers of 11 drugs targeting either the RTK/Ras/PI3K, the p53 or the Rb pathway using 25 patient-derived glioblastoma stem-like cell cultures (GSCs).

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<i>TP53</i> mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in <i>TP53</i> wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2