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Materials and methods. Forty-eight patients were allo-transplanted between January 2012 and January 2016 including 22 patients (46%) from fully HLA-matched related donors, and 26 (54%), from haploidentical donors. Their median age was 34 (2-65) years old. Acute lymphoblastic leukemia was the most common diagnosis (79% of patients). Twenty-nine (60%) patients received myeloablative conditioning (MAC), and 19 (40%) were administered a reduced intensity conditioning (RIC). In alloSCT from fully HLA-matched related donors, we used peripheral blood stem cells in 12 (54%) patiens, and bone marrow in 10 (46%) patients; in all haploSCT we used bone marrow as a source of stem cells. All the patients received aGVHD prophylaxis with HDCY (50 mg/kg) day+3 and +4, haploSCT patients received also Tacrolimus and Mycophenolate Mofetil.

cellular therapy and transplantation

High-dose cyclophosphamide after allogeneic stem cell transplantation as a graft-versus-host-disease prophylactic agent in adult acute leukemia: Experience of two Mexican hospitals