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Multipotent mesenchymal stromal cells (MSCs) possess immunomodulatory properties and were successfully used for treatment of autoimmune diseases and acute or chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cells transplantation. Therapy with MSCs is not always effective. It has been shown that immunomodulatory properties of the MSCs may be improved by means of various agents, such as IFN-γ, TNF-α, IL-17. Characteristics of MSCs after injection into the patients differ from those which have been studied in culture, due to their interactions with other cells in bloodstream and tissues. In this study, an attempt was made to develop a model of IFN-γ-treated MSCs (IFN-γ-MSC) and their in vitro interactions with allogeneic lymphocytes. The aim of the study was to identify the changes of MSCs and IFN-γ-MSC characteristics after co-cultivation with lymphocytes in vitro and to determine the level of expression of CD90 (Thy-1) – MSCs marker characterizing the degree of differentiation, in dynamics.

Alterations in multipotent mesenchymal stromal cells properties: in vitro model of their interactions with allogeneic lymphocytes