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There are no any widely accepted recommendations for management of immunologic graft rejection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A number of possible approaches increase therapeutic risk due to high toxicity and severe side effects. Our aim was to evaluate the Fludarabine-based immunodepletion therapy followed by donor lymphocytes infusion (DLI) for treatment of early immunological hematopoietic graft rejection after allo-HSCT.

cellular therapy and transplantation

Successful usage of fludarabine for treatment of partial immunologic hematopoietic graft rejection after allogeneic hematopoietic stem cell transplantation in pediatric patients