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Regulatory Т cells (Тregs) play an important role in pathogenesis of multiple myeloma (MM), providing tumor cell avoidance of immune surveillance. The latter, in turn, are able to induce the Treg expansion. However the data on their contents at different stages of disease and their relations to efficiency of the therapy performed are incomplete and controversial. The aim of this study was to investigate dynamics of CD4+FOXP3+ regulatory T cells (Treg) recovery following high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell transplantation (AHSCT), and possible relationship between Tregs and clinical outcomes in multiple myeloma (MM) patients.

cellular therapy and transplantation

Regulatory T cells affect early relapse following high-dose chemotherapy with autologous hematopoietic stem cell transplantation in multiple myeloma patients